19 research outputs found
Measurement and comparison of individual external doses of high-school students living in Japan, France, Poland and Belarus -- the "D-shuttle" project --
Twelve high schools in Japan (of which six are in Fukushima Prefecture), four
in France, eight in Poland and two in Belarus cooperated in the measurement and
comparison of individual external doses in 2014. In total 216 high-school
students and teachers participated in the study. Each participant wore an
electronic personal dosimeter "D-shuttle" for two weeks, and kept a journal of
his/her whereabouts and activities. The distributions of annual external doses
estimated for each region overlap with each other, demonstrating that the
personal external individual doses in locations where residence is currently
allowed in Fukushima Prefecture and in Belarus are well within the range of
estimated annual doses due to the background radiation level of other
regions/countries
Investigation of lanthanum and hafnium-based dielectric films by X-ray reflectivity, spectroscopic ellipsometry and X-ray photoelectron spectroscopy
International audienc
Electrical properties and interfacial characteristics of RuO2/HfAlOx/SiON/Si and RuO2/LaAlO3/SiON/Si capacitors
International audienc
HMGB1 as an autocrine stimulus in human T98G glioblastoma cells: role in cell growth and migration.
HMGB1 (high mobility group box 1 protein) is
a nuclear protein that can also act as an extracellular trigger
of inflammation, proliferation and migration, mainly
through RAGE (the receptor for advanced glycation end
products); HMGB1\u2013RAGE interactions have been found to
be important in a number of cancers. We investigated
whether HMGB1 is an autocrine factor in human glioma
cells. Western blots showed HMGB1 and RAGE expression
in human malignant glioma cell lines. HMGB1
induced a dose-dependent increase in cell proliferation,
which was found to be RAGE-mediated and involved the
MAPK/ERK pathway. Moreover, in a wounding model, it
induced a significant increase in cell migration, and RAGEdependent
activation of Rac1 was crucial in giving the
tumour cells a motile phenotype. The fact that blocking
DNA replication with anti-mitotic agents did not reduce the
distance migrated suggests the independence of the proliferative
and migratory effects. We also found that glioma
cells contain HMGB1 predominantly in the nucleus, and
cannot secrete it constitutively or upon stimulation;
however, necrotic glioma cells can release HMGB1 after it
has translocated from the nucleus to cytosol. These findings
provide the first evidence supporting the existence of
HMGB1/RAGE signalling pathways in human glioblastoma
cells, and suggest that HMGB1 may play an
important role in the relationship between necrosis and
malignancy in glioma tumours by acting as an autocrine
factor that is capable of promoting the growth and migration
of tumour cells.
Keywords ERK1/2 HMGB1 Human gliomas
Motilit
EFFECTS OF NITROGEN INCORPORATION IN LANTHANUM-BASED DIELECTRIC FILMS
International audienc